Amaç: Medyan sinirin el bileğinde karpal tünel içinde sıkışması sonucu meydana gelen karpal tünel sendromu (KTS), en sık görülen tuzak nöropatidir. Genellikle sebebi idiopatik olup; inflamatuar ve endokrin bozukluklarında sıklığı artar. Etiyolojisi tam olarak açıklanmamıştır. Amino asitler (AA), çeşitli biyolojik fonksiyonlara sahip olup yaşam aktivitelerinde önemli bir madde sınıfıdır; enerji metabolizmasında rol oynayan proteinlerin bileşimi ve nörotransmitterler, nükleik asitler ve koenzimler gibi azot içeren bileşiklerin öncüleridir. Literatür taramamızda KTS’de AA incelemesi yapan çalışmaya rastlamadık. Bu anlamda ilk olan bu çalışmada patofizyolojiyi aydınlatmak ve tedaviye yardımcı olabilmek için AA seviyelerini incelemeyi amaçladık. Gereç ve Yöntemler: Çalışmaya; elektromyografi sonucuna göre KTS tanısı konulan hastalar dâhil edildi. Hastalar kendi içinde idiopatik KTS ve sekonder KTS olarak ayrılıp ayrıca aynı yaş ve cinsiyete uygun kontrol grubu da alındı. Hastaların plazmalarından uygun kit ile plazma serbest AA seviyeleri incelendi. Bulgular: 44 AA’dan 26 tanesi anlamlı olarak analiz edildi. İdiopatik KTS’de sistatin, glisin, beta alanin, 1- Methyl-L-histidin, asparajin, prolin değerleri daha düşük gözlenirken; 2-aminoadipik asit, anserin, lösin, arginin, glisin, histidin, fenilalanin değerleri daha yüksekti. Sekonder KTS’li hastalar hem idiopatik hem de kontrol grubuyla anlamlı farklılıklar gösterdi. Sonuç: KTS’li hastalarda farklılık gösteren AA’lar patogenezden sorumlu olabilir. Ayrıca düşük olanların takviye edilmesi veya yüksek olanların altta yatan sebeplerinin ortadan kaldırılmasının hastalık gelişimini engelleyeceğini düşünmekteyiz.

Objective: Carpal tunnel syndrome, which occurs as a result of compression of the median nerve in the carpal tunnel in the wrist, is the most common entrapment neuropathy. The most common cause is idiopathic; its frequency is increased in inflammatory and endocrine disorders. Its etiology has not been fully explained. Amino acids have various biological functions and are an important class of substances in life activities; it is a composition of proteins involved in energy metabolism and precursors of nitrogen-containing compounds such as neurotransmitters, nucleic acids and coenzymes. In our literature review, we did not find any studies examining amino acids in carpal tunnel syndrome. In this first study, we aimed to examine amino acid levels to elucidate the pathophysiology and assist in treatment. Material and Methods: Patients diagnosed with carpal tunnel syndrome based on electromyography results were included. The patients were divided into idiopathic CTS and secondary CTS, and a control group of the same age and gender was also included. Levels of 44 amino acids from the patients’ plasma were examined with the appropriate kit. Results: 26 amino acids were significant. While cystatin, glycine, beta alanine, 1-Methyl-L-histidin, asparagine and proline values are lower in idiopathic carpal tunnel syndrome; aminoadipic acid 2, anserine, leucine, arginine, glycine, histidine, phenyl alanine values were higher. Patients with secondary carpal tunnel syndrome showed significant differences with both the idiopathic and control groups. Conclusion: These amino acids may be responsible for the pathogenesis in carpal tunnel syndrome.

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