ISSN: 1309 - 3843 E-ISSN: 1307 - 7384
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DERLEMELER

SARS-COV-2: Çeşitli Belirtiler Hakkında Güncel Bir Derleme
SARS-COV-2: A Current Update About Miscellaneous Symptoms
Received Date : 24 Feb 2021
Accepted Date : 27 Jun 2021
Available Online : 06 Jul 2021
Doi: 10.31609/jpmrs.2021-82578 - Makale Dili: EN
J PMR Sci. 2021;24(3):294-8
ÖZET
Şiddetli akut solunum sendromu-koronavirüs-2 [severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)] partikülü, genetik zemine bağlı olarak konakta farklı klinik yanıtlara neden olur ve iyileşmeden sonra uzun süreli semptomlar gelişebilir. Günümüzün bilgisiyle, SARS-CoV-2 enfeksiyonunu bir otoimmün viral vaskülopati kliniğinin nedeni olarak tanımlayabiliriz. Mevcut bilgilerimizle hangi hastaların şiddetli veya uzun süreli hastalık geliştireceği net değildir. Kronik ağrı, yorgunluk, sarkopeni, vaskülopati, otoimmün bozukluklar, artrit ve santral sensitizasyon gibi SARS-CoV-2 ile ilişkili semptomlara neden olan birçok farklı patofizyolojik mekanizma vardır. SARS-CoV- 2’nin birçok hayati organda mikrotromboz ve endotel disfonksiyonunun sonucu immün yanıt ve yaşamı tehdit eden durumlara neden olduğunu artık biliyoruz. Ayrıca konakta bir immün yanıtı tetikler. Bu immün reaksiyon, uzun vadede otoimmün hastalıkları tetikleyebilir. Bu derlemede, sistemik komplikasyonların yanı sıra özellikle bir fiziyatrist bakış açısından virüsün neden olduğu çeşitli semptomlara odaklandık.
ABSTRACT
Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) particle causes different clinical responses in the host depending on the genetic background and prolonged symptoms may develop after recovery. With today's knowledge, we may describe SARS-CoV-2 infection the cause of an autoimmune viral vasculopathy clinic. With our current information, it is not clear which patients will develop severe or prolonged disease. There are many different pathophysiological mechanisms that cause coronavirus disease-2019 related symptoms like chronic pain, fatigue, sarcopenia, vasculopathy, autoimmun disorders, arthritis and central sensitization etc.We now know that SARS-CoV-2 causes immune response and life-threatening conditions as a result of microthrombosis and endothelial dysfunction in many vital organs. Also it triggers an immune response in the host. This immun reaction may trigger autoimmune diseases in the long term. In this review, we especially focused on miscellaneous symptoms caused by virus, from the perspective of a physiatrist, besides systemic complications.
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