ISSN: 1309 - 3843 E-ISSN: 1307 - 7384
FİZİKSEL TIP VE REHABİLİTASYON
BİLİMLERİ DERGİSİ
www.jpmrs.com
Kayıtlı İndexler



Ev-Bazlı Aerobik Egzersiz Programının Behçet Hastalarında Kanama Profili ve İnflamasyon Üzerine Etkisi
Effect of Home-Based Aerobic Exercise Program on Bleeding Profile and Inflammation’ in Patients with Behçet's Disease
Received Date : 03 Feb 2020
Accepted Date : 03 May 2020
Available Online : 23 Jul 2020
aSütçü İmam University Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Kahramanmaraş, TURKEY bSütçü İmam University Faculty of Medicine, Department of Clinic Biochemistry, Kahramanmaraş, TURKEY cSütçü İmam University Faculty of Medicine, Department of Dermatology, Kahramanmaraş, TURKEY
Doi: 10.31609/jpmrs.2020-74069 - Makale Dili: EN
J PMR Sci
ÖZET
Objective: Sedentary lifestyle is a major risk factor for cardiovascular disease (CVS) and thrombotic complications. The effect of different types of exercise on platelet function has been the subject of a limited number of studies. Behçet's disease is a multisystemic disease characterized by recurrent oral and genital aphthous lesions and uveitis with unknown etiology. There is an unknown cause of the disease and hyperactivation of the procoagulant cascade and associated mortality due to arterial and venous thrombosis. Here, the effect of aerobic exercise on the bleeding profile and acute phase reactants in Behçet's patients was analyzed experimentally. Material and Methods: Twenty-four (n=24) patients with Behcet's disease were included in the study. Age, height, weight, sex, smoking, known systemic disease (such as diabetes, hypertension, thyroid) and vascular claudication were investigated. Those who didn’t complete the protocole (n=5) were excluded from the study. Before and after moderate intensity aerobic exercise program (4 weeks, 3 times a week, 45 minutes per day) sedimentation (ESR), C-reactive protein (CRP), bleeding profile including prothrombin time (PT), prothrombin time percentage (PT%), activated prothrombin time (aPTT), platelet, collagen epinephrine, collagen adenosine diphosphate (ADP) and international normalized ratio (INR) were recorded. Results: N=19 patients with Behçet's disease were enrolled. The mean age was 37.8±9.8 years. The mean body mass index (BMI) was 28.6±5.5 kg/m2. Vascular claudication was present in 9 patients (47.4%), smoking was in 1 patient (5.3%), and hypertension (10.5%) was present in 2 patients. While ESR (p=0.028) and collagen ADP (p=0.02) decreased after exercise; platelet count (p=0.005), Aptt (p=0.08), PT (p=0.022) and PT% (p=0.014) were increased. Conclusion: Increase in the duration of aggregation and decrease in inflammation after the exercise program supports that thrombosis can be prevented by exercise. We conclude that short term home-based aerobic exercise program has positive effect on homeostasis in patients with Behçet's disease.
ABSTRACT
Objective: Sedentary lifestyle is a major risk factor for cardiovascular disease (CVS) and thrombotic complications. The effect of different types of exercise on platelet function has been the subject of a limited number of studies. Behçet's disease is a multisystemic disease characterized by recurrent oral and genital aphthous lesions and uveitis with unknown etiology. There is an unknown cause of the disease and hyperactivation of the procoagulant cascade and associated mortality due to arterial and venous thrombosis. Here, the effect of aerobic exercise on the bleeding profile and acute phase reactants in Behçet's patients was analyzed experimentally. Material and Methods: Twenty-four (n=24) patients with Behcet's disease were included in the study. Age, height, weight, sex, smoking, known systemic disease (such as diabetes, hypertension, thyroid) and vascular claudication were investigated. Those who didn’t complete the protocole (n=5) were excluded from the study. Before and after moderate intensity aerobic exercise program (4 weeks, 3 times a week, 45 minutes per day) sedimentation (ESR), C-reactive protein (CRP), bleeding profile including prothrombin time (PT), prothrombin time percentage (PT%), activated prothrombin time (aPTT), platelet, collagen epinephrine, collagen adenosine diphosphate (ADP) and international normalized ratio (INR) were recorded. Results: N=19 patients with Behçet's disease were enrolled. The mean age was 37.8±9.8 years. The mean body mass index (BMI) was 28.6±5.5 kg/m2. Vascular claudication was present in 9 patients (47.4%), smoking was in 1 patient (5.3%), and hypertension (10.5%) was present in 2 patients. While ESR (p=0.028) and collagen ADP (p=0.02) decreased after exercise; platelet count (p=0.005), Aptt (p=0.08), PT (p=0.022) and PT% (p=0.014) were increased. Conclusion: Increase in the duration of aggregation and decrease in inflammation after the exercise program supports that thrombosis can be prevented by exercise. We conclude that short term home-based aerobic exercise program has positive effect on homeostasis in patients with Behçet's disease.